Medically reviewed by Drugs.com. , Paton et al. Forskolin derivatives have been developed for use in cardiovascular conditions. It has been used for over 3,000 years in Ayurvedic Medicine. Coleus forskohlii = Plectranthus barbatus Coleus rotundifolius = Plectranthus rotundifolius Sanggunian. Europe Coleus Forskohlii Extract Market 2020 is Evolving Rapidly with Economic Growth, Demand, and Forthcoming … A concentration-dependent inhibition of vascular contractility was demonstrated in rat aorta, and a vasodilator action in rats and rabbits has been shown.Alasbahi 2010, In human heart tissues, forskolin activated AC and demonstrated strong positive inotropic properties that were synergistic with isoproterenol.Bristow 2004 Older, small clinical studies have demonstrated that forskolin improves coronary blood flow and myocardial and left ventricular function and increases the blood flow in the cerebrum and kidneys.Alasbahi 2010, Due to poor water solubility and low oral bioavailability, clinical use of forskolin is limited and has led to development and study of colforsin (NKH477), a water-soluble derivative. Available for Android and iOS devices. Forskolin has also been used to treat heart, blood, and circulation conditions, and cancers. Some of the species within the genus are difficult to distinguish, leading to unclear taxonomy. Chú thích Liên kết ngoài. The Forskolin extracted from the roots of coleus Forskohlii … In India, the plant is cultivated for use in pickles.Alasbahi 2010, Insel 2003, Alasbahi 2010, The main constituents of P. barbatus are the diterpenoids and essential oil. Forskolin appears to work in a way similar to certain types of conventional asthma drugs, by boosting the levels of a compound called cyclic AMP. Loài này được (Willd.) We comply with the HONcode standard for trustworthy health information -. Adverse events were not reported.Godard 2005 A trial conducted among women at the same dosage found no changes in body fat and concluded that forskolin does not promote weight loss.  Species include:, https://en.wikipedia.org/w/index.php?title=Coleus&oldid=984532807, Articles containing potentially dated statements from July 2020, All articles containing potentially dated statements, Creative Commons Attribution-ShareAlike License, This page was last edited on 20 October 2020, at 16:02. The root is used as medicine. , A preliminary study of the tribe Ocimeae in 2004 showed that the subtribe Plectranthinae was monophyletic, with two main clades: one containing the type species of Coleus and including Solenostemon, the other containing the type species of Plectranthus along with some other genera, so that Plectranthus when broadly defined was not monophyletic. Outside this plant needs total shade or only the most mild morning sunlight.. Coleus and Solenostemon were sunk into Plectranthus, but recent phylogenetic analysis found Plectranthus to be paraphyletic with respect to other related genera in the subtribe Plectranthinae. P. barbatus is a perennial herb in a large genus of mints. Two older studies suggested that topically applied forskolin cream reduced localized fat in the thighs of obese women without the need for diet or exercise.Alasbahi 2010 A small (N = 30), randomized clinical trial conducted in obese men found a decrease in body fat, increase in bone mass, and a trend toward changes in lean body mass following 12 weeks of forskolin versus placebo. Synonyms include Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus kilimandschari, Plectranthus grandis, Coleus forskohlii, Coleus barbatus, and Coleus coerulescens.The plant is native to subtropical and tropical regions of India and East Africa, grows to a height of 60 cm, and has large, soft leaves. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. It has aromatic green leaves that grow off erect stems, and can reach heights of 2 feet. Select one or more newsletters to continue. The Plant List, entry for Solenostemon, retrieved June 12, 2015 1. 1. In ancient Sanskrit texts it is known as Makandi and was said to … Of the 30 subjects who completed the trial, 6 were male. This information relates to an herbal, vitamin, mineral or other dietary supplement. Cyclic AMP is a “second messenger” hormone signaling system. Experimental studies on various cancer cell lines have shown synergistic effects of forskolin in upregulating cellular responses.Lekmine 2008, Watanabe 2004, Watanabe 2005, Tong 2004, Li 2006, Kim 2004 A protective effect against ionizing radiationSolovjeva 2009 and UBV-induced apoptosisPasseron 2009 has been shown in vitro. In 1962, J.K. Morton noted that fused stamens were more widespread than previously thought, and accordingly merged Coleus into Plectranthus, while maintaining Solenostemon and some other genera as distinct. Dr. Oz doesn't know it but he’s responsible for a lot of the emails I get. P. barbatus is a perennial herb in a large genus of mints. Tropicos.org, retrieved June 12, … Through forskolin, Coleus forskohlii … 100 … Plectranthus barbatus, also known by the synonym Coleus forskohlii is a tropical perennial plant related to the typical coleus species. Coleus Forskohlii or Plectranthus barbatus is a tropical perennial plant from the mint family. Information regarding safety and efficacy in pregnancy and lactation is lacking. Coleus is a genus of annual or perennial herbs or shrubs, sometimes succulent, sometimes with a fleshy or tuberous rootstock, found in the Old World tropics and subtropics. Coleus root contains a chemical called forskolin. If direct sunlight touches the plant's leaves, the colors become less brightly colored. in 2019 published a summary cladogram for the subtribe Plectranthinae, based on a study in 2018. barbatus）とはインドやネパールに自生するシソ科の植物でインドの伝統医学・アーユルヴェーダにおいて用い … This is only a brief summary of general information about this product. Although Coleus was previously sunk into Plectranthus, the original binomial was revived in a major study of the subtribe Plectranthinae in 2019. In the 1970s, the plant's cardiovascular activity was investigated, while the discovery that the diterpene forskolin directly activates adenylate cyclase (AC) was also made.Lukhoba 2006, Alasbahi 2010, Seamon 2981 Research is largely limited to the use of radiolabeled forskolin to quantify AC and to investigate analogs of forskolin. Potentiation of the antiplatelet effect of prostaglandins and aspirin has been demonstrated in vitro. It grows in tropical regions of Asia such as Nepal, India, and Thailand. Asthma: Oral forskolin has been studied using 10 mg daily over 2 to 6 months. Media in category "Plectranthus barbatus" The following 48 files are in this category, out of 48 total. Coleus forskohlii is a tropical plant native to Southern Asia and is related to the lavender and mint family. The many new binomial combinations needed to implement this approach were provided in 2019. The most recent taxonomic treatment of the genus resurrected Coleus, and 212 names were changed from combinations in Plectranthus, Pycnostachys and Anisochilus. Scientific Name(s): Coleus barbatus, Coleus coerulescens, Coleus forskohlii auct., Plectranthus barbatus Andrews, Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus grandis, Plectranthus kilimandschariCommon Name(s): Adel Inj, Asthma X-5, Ele-max, Forskolin, ForsLean, GlucoLean, HL-362, Indian coleus, Interex, Makandi, Mao hou qiao rui hua, Meta-Burn EF, NKH477, Pashanabhedi. Quality clinical trials are lacking to substantiate claims made of the weight loss properties of forskolin, and clinical studies conducted with oral and inhaled forskolin in patients with asthma are limited. For example, in a recent segment of the Dr Oz Show, an herb called Coleus forskohlii (also called forskolin) was said to be one of the secrets to weight loss.I first reviewed Coleus forskohlii … are highlighted. Coleus forskohlii Examples of in a sentence. Plectranthus barbatus is a synonym of Coleus forskohlii 184.108.40.206 07:24, 23 October 2010 (UTC)msjs08 g mail com220.127.116.11 07:24, 23 October 2010 (UTC) "Muscules" ? Adenylate cyclase is the enzyme involved in the production of Cyclic Adenosine Monophosphate (cAMP), a significant biochemical agent in metabolic processes. Coleus is a member of the Lamiaceae or Mint family and smells like camphor. You should talk with your health care provider for complete information about the risks and benefits of using this product. Subjects in the forskolin group exhibited significantly improved insulin levels (P=0.001) and insulin resistance (P=0.01) compared to controls; however, no significant differences were observed between groups for lipid parameters, blood glucose, or the appetite hormones ghrelin or leptin. Other species that produce root tubers are cultivated for food, including Coleus esculentus, Coleus rotundifolius and Coleus maculosus subsp. I'm assuming that … Coleus is a genus of annual or perennial herbs or shrubs, sometimes succulent, sometimes with a fleshy or tuberous rootstock, found in the Old World tropics and subtropics. The most recent taxonomic treatment of the Coleus forskohlii is the only known natural source of the unique adenylate cyclase activating phytonutrient, forskolin3. , Coleus are cultivated as ornamental plants, particularly Coleus scutellarioides (syns. Some of the species within the genus are difficult to distinguish, leading to unclear taxonomy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Approximately 70 diterpenoids have been described in the leaves, roots, and whole plant, with forskolin (also known as coleonol) being one of the most active compounds.Alasbahi 2010, Because forskolin has been actively pursued as a drug development lead, many analytical chemistry studies exist, and commercially available preparations can be standardized by forskolin content.Alasbahi 2010 Tissue culture methods for forskolin production have also been successfully explored because the relatively modest content of forskolin in the plant has limited its development as a drug.Mersinger 1988, Mukherjee 2000. Coleus forskohlii is an herb that’s been used for many years – especially in ayurvedic traditional medicine. Traditional medical uses include the treatment of digestive disorders (stomachache, gastric and intestinal spasm, nausea, as a purgative), skin (burns, wounds, insect bites, allergies), infections (eg, syphilis, ringworm), and other conditions, including neck stiffness, and rheumatism, and as an emmenagogue and oral contraceptive. The principle mechanism by which forskolin exerts its activity is by stimulation of AC, thereby increasing cellular cAMP, which is involved in processes such as glycogen and lipid metabolism. Coleus barbatus was first described by Henry Cranke Andrews in 1810 as Plectranthus barbatus. An increase in serum testosterone was also demonstrated. Used for allergic conditions such as asthma and eczema, … The relationship among the genera Coleus, Solenostemon and Plectranthus has been confused. Wiki content for Coleus Forskohlii. that formed part of Plectranthus s.l. Growing Coleus from Seeds Start the seeds in early spring. Information is limited. Coleus forskohlii là một loài thực vật có hoa trong họ Hoa môi. Embryo-related toxicity has been reported. It was transferred to Coleus by Bentham in 1830. Last updated on Sep 7, 2020. It is composed of about 150 species under the Mint family of plants … This plant prefers bright, but indirect sunlight. As a consequence of gluconeogenesis, interference with medicines used in diabetes may be expected.Alasbahi 2010, Forskolin-like substances have been identified in renal cyst fluid; therefore, forskolin should be avoided in patients with polycystic kidney disease.Putnam 2007, Large doses in mice have been reported to have a depressant action on the CNS, and perianal dermatitis has been reported with the use of whole plant extracts.Lukhoba 2006, Alasbahi 2010 Clinical trial data are generally lacking; however, a clinical trial found no changes in various metabolic markers or laboratory indices, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005 Adverse events reported with the use of colforsin (a forskolin derivative) include tachycardia and arrhythmias.Alasbahi 2010, Hayashida 2001, Toxicology information is limited. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Coleus and Solenostemon were sunk into Plectranthus, but recent phylogenetic analysis found Plectranthus to be paraphyletic with respect to other related genera in the subtribe Plectranthinae. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. This information is not specific medical advice and does not replace information you receive from your health care provider. Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine). The oral median lethal dose in rats has been reported to be more than 2,000 mg/kg body weight.Huerta 2010 The hydroalcoholic extract of the plant has been shown to interfere with embryonic implantation and to delay fetal development.Almeida 2000. Today, Coleus forskohlii is used as a fat burning supplement. Chemical modification of forskolin at the 6- and 7-positions has led to semisynthetic compounds, with modest selectivity for particular cyclase isoforms, including the cardiac type 5 AC. Stimulation of AC is thought to be the mechanism by which forskolin relaxes a variety of smooth muscles; however, forskolin has been found to act through other systems, including glucose transport and ion channels.Seamon 1981, Insel 2003, Alasbahi 2010, Iwatsubo 2003, Wessler 2003, Forskolin has been shown in vitro to inhibit platelet aggregation through AC stimulation, augmenting the effects of prostaglandins.Siegl 1982, Adnot 1982 An inhibitory effect on C-kinase activation in platelets has also been described.Alasbahi 2010, Antithrombotic properties have been demonstrated in experiments in rats, rabbits, and sheep.Alasbahi 2010. This information should not be used to decide whether or not to take this product. The root has been used in traditional Indian medicine for centuries to treat heart disease, lung … Coleus is a plant from the mint family. Forskolin has been demonstrated to have an angiogenic effect via cAMP-dependent protein kinase pathways.Namkoong 2009, Positive inotropic action has been demonstrated in isolated guinea pig, rabbit, and human heart tissue, and in vivo in cats and dogs. In modern medicine, coleus forskohlii … It is closely related to basil, peppermint, thyme and salvia, but unlike most of these the fibrous roots of coleus is used for medicinal purpose. No changes in various metabolic markers or laboratory indices were found, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005, Forskolin has been used in animal and limited clinical studies in glaucoma, with only temporary effects reported.Alasbahi 2010, In addition to smooth muscle relaxant properties, forskolin also exerts activity on inflammatory mediators, including interleukins and histamine, and on calcium ion influx, leading to its evaluation in asthma.Alasbahi 2010, Huerta 2010, In guinea pigs, forskolin blocked bronchospasm caused by inflammatory mediators (histamine, leukotriene-4) and antigens. Coleus blumei, Plectranthus scutellarioides), which is popular as a garden plant for its brightly colored foliage. It comes from a tropical plant also named plectranthus barbatus. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Adverse events reported with the use of colforsin (a forskolin derivative) include tachycardia and arrhythmias. Oral forskolin performed better than sodium chromoglycate in preventing asthma attacks in children and adults with mild/moderate persistent asthma, while inhaled forskolin was not superior to beclomethasone in lung function improvement. Coleus forskohlii is an herb historically used in Ayurveda (Ayurvedic medicine).. Today, Coleus forskohlii is used as a fat burning supplement. Briq. Coleus forskohlii is considered to be the wild ancestor of all the tuber varieties, known as Kaffir Potatoes. Using morphological characters as a guide, it was distinguished from Plectranthus (first described by Charles L'Héritier in 1788) by having its four stamens fused together rather than free to the base.  Most sources followed Morton in submerging Coleus; some kept Solenostemon distinct, although others submerged it into Plectranthus along with Coleus. P. barbatus has been traditionally used as an emmenagogue and oral contraceptive. In many hormone sensitive systems the hormone itself does not enter the target cell but binds to a receptor and indirectly affects the production of another mo… P. barbatus has been traditionally used as an emmenagogue and oral contraceptive.Lukhoba 2006, Almeida 2000 Forskolin delayed spontaneous meiotic progression in human oocytes in an in vitro fertility study.Shu 2008, None reported, but interactions with CYP3A-dependent drugs are theoretically possible. Synonyms include Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus kilimandschari, Plectranthus grandis, Coleus forskohlii, Coleus barbatus, and Coleus coerulescens. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Forskolina, ou forscolina, cujo nome deriva do anterior nome binomial da espécie, Coleus forskohlii, é um importante constituinte de Plectranthus barbatus, a única fonte comercialmente significativa daquele … Forskolin increases cellular levels of a molecule called cyclic … The genus Coleus was first described by João de Loureiro in 1790. Content of the essential oil depends on location and time of harvesting, and mainly consists of mono- and sesquiterpenes. Forskolin should be avoided in patients with polycystic kidney disease. coleus forskohlii coleus forskohlii I still don’t know how to pronounce it, but it’s a super amazing ayurvedic herb in the mint/lavender family. Forskolin is available under the following different brand names: coleus forskohlii, colforsin, makandi, maohouqiaoruihua, and pashanabhedi. Coleus (ou cóleus) é a designação comercial e o nome comum de um conjunto de espécies da família Lamiaceae utilizadas como plantas ornamentais.A designação correspondia ao nome genérico do antigo género Coleus … A more detailed study in 2018 reached similar conclusions, and suggested that Coleus (including Solenostemon) should be recognized again, Plectranthus more narrowly defined, and a new genus, Equilabium erected for a clade of former Plectranthus species mainly from tropical Africa. Forskolin (coleus forskohlii) with Asthma and Allergies Forskolin is an effective smooth muscle relaxer, resulting in bronchodilation, decreased airway resistance, increased vital capacity and increased … mô tả khoa học đầu tiên năm 1897. Clustered purple-blue flowers appear from fall to late spring.PLANTS 2007, Lukhoba 2006, Alasbahi 2010, This species and other related species have been used extensively in many traditional medical systems, including those of Brazil, eastern, and central Africa, as well as India and other Asian countries. Adverse events were not reported.Huerta 2010, González-Sánchez 2006 Colforsin has also been evaluated as a bronchodilator in a limited number of studies.Wajima 2002, Wajima 2003, Bauer 1993, Studies in animals have shown various effects of forskolin, including induction of melatonin production in the pineal glands, increased melanin in hair follicles leading to an increase in pigmentation, increased hair growth, and a protective effect against ultraviolet B light (UBV)-induced apoptosis.Alasbahi 2010, Chen 2009, Lekmine 2008, Passeron 2009, Case reports exist showing improvement of psoriatic symptoms and a decrease in erythema in patients with hyperplastic skin disorders.Alasbahi 2010, Oral forskolin has been studied using 10 mg daily over 2 to 6 months.Huerta 2010, González-Sánchez 2006, 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied.Godard 2005, Henderson 2005, Information regarding safety and efficacy in pregnancy and lactation is lacking. (2019) list 294 species of Coleus, many transferred from Plectranthus. Coleus Forskohlii (Plectranthus barbatus) – Attribution: Jurema Oliveira Therapeutic Uses, Benefits and Claims of Coleus Forskohlii Coleus is a not a particularly remarkable plant to look at, yet it has a 3000 … Obesity/Metabolic syndrome: 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied. Coleus Herb Claims* C. forskohlii is claimed to support healthy heart, lung, gastrointestinal and immune function, as well as help hypertension (high blood pressure), asthma, … This product may be unsafe when used before surgery or other medical procedures. A colforsin preparation (Adehl) is approved for use in Japan, and limited studies have been conducted in cardiac surgery, heart failure, and cerebral vasospasm.Alasbahi 2010, Kikura 2004, Hayashida 2001, Suzuki 2006, The use of forskolin in studies involving the CNS is largely related to elucidating the role of cAMP in depression and other cellular processes.Cohen 2004, Gobert 2008, Seo 2009, Radiolabeled forskolin was shown to bind to rat brain membranes in a saturable and specific manner.Seamon 1984 Forskolin demonstrated potent antidepressant activity in a rat forced swimming modelMaeda 1997 and prevented induced seizures in mice.Alasbahi 2010, Clinical trials are lacking; however, case studies using intravenous infusions of forskolin demonstrated a transient elevation in mood in some depressed and schizophrenic patients.Alasbahi 2010, Stimulation of the release of pancreatic insulin and glucagon by forskolin has been demonstrated in vitro.Alasbahi 2010 Influence of forskolin on glucose transport and the action of insulin in skeletal muscle has also been described.Niu 2003, Richmond 2009, Ding 2003 Clinical trials are lacking; however, studies in normal and diabetic rats have shown increases in blood glucose and serum insulin.Alasbahi 2010, Due to its vasodilating properties, forskolin and analogs have been proposed for intercavernosal treatment of erectile dysfunction; however, only small clinical studies have been reported.Drewes 2003, Mulhall 1997 An in vitro study demonstrated increased bovine and human sperm motility with forskolin.Liu 2003, Animal studies have shown that forskolin promotes gastric and pancreatic acid secretion, as well as relaxes intestinal smooth muscle.Alasbahi 2010, Forskolin has been shown to influence cellular immune responses in vitro and in animal experiments.Alasbahi 2010, A double-blind, randomized, placebo-controlled trial conducted in 41 overweight or obese participants evaluated the effect of C. forskohlii extract on appetite hormones and insulin sensitivity. コレウス・フォルスコリ（学名：Plectranthus barbatus、シノニム：Coleus forskohlii、C. Clinical trial data are generally lacking. The main bioactive ingredient in Coleus forskohlii is called forskolin. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Forskolin augmented coronary blood flow in guinea pig hearts and increased heart rate and decreased blood pressure in dogs, cats, rabbits, and rats. Relaxation of the bronchioles has also been demonstrated in isolated ovine tissue.Alasbahi 2010, Limited single-blinded clinical studies have been conducted with oral and inhaled forskolin in patients with asthma and in healthy volunteers. The intervention was well tolerated.Loftus 2015, A patent claiming promotion of lean body mass and antidepressant activity of a forskolin-containing extract was granted to the supplement company Sabinsa in 1998, and another patent was awarded in 2006.Alasbahi 2010, Majeed 1997, Animal models of obesity have been used by the patent holder to demonstrate decreases in body weight and fat.Alasbahi 2010 In vitro studies suggest forskolin acts via cAMP but in a more complex manner than that of increased AC levels.Alasbahi 2010, Okuda 1992, Quality clinical trials are lacking to substantiate claims made of the antiobesity properties of forskolin.
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